JAK-IN-21 is a selective and potent inhibitor of Janus kinase (JAK), demonstrating inhibitory concentrations (IC50) of 1.73 nM for JAK1, 2.04 nM for JAK2, 109 nM for the J2V617F mutant, and 62.9 nM for TYK2. This compound is useful in research applications focused on elucidating the role of JAK signaling pathways in various diseases, including hematological malignancies and autoimmune disorders. JAK-IN-21 serves as a valuable tool for studying the therapeutic potential of JAK inhibition.
JAK-IN-21 is a selective and potent inhibitor of Janus kinase (JAK), demonstrating inhibitory concentrations (IC50) of 1.73 nM for JAK1, 2.04 nM for JAK2, 109 nM for the J2V617F mutant, and 62.9 nM for TYK2. This compound is useful in research applications focused on elucidating the role of JAK signaling pathways in various diseases, including hematological malignancies and autoimmune disorders. JAK-IN-21 serves as a valuable tool for studying the therapeutic potential of JAK inhibition.
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