JAK3-IN-2

Name: JAK3-IN-2
SKU: A18323

目录号: A18323

JAK3 抑制剂

JAK3-IN-2 Chemical Structure

CAS NO. 1443235-95-7

JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.

库存：现货

规格	价格	数量
5 mg	￥ 800.00
10 mg	￥ 1,400.00
50 mg	￥ 4,200.00
100 mg	￥ 7,500.00

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生物活性

溶解度 *

In vitro	DMSO	69 mg/mL (196.93 mM)
	Water	Insoluble
	Ethanol	9 mg/mL (25.68 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.54 mL	142.7 mL	285.41 mL
0.5 mM	5.71 mL	28.54 mL	57.08 mL
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL

*The above data is based on the productmolecular weight 350.378. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18323
作用机制	Inhibitor (抑制剂)
M. Wt	350.378
Formula	C19H18N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1443235-95-7
Synonyms	JAK3 inhibitor 2
SMILES	O=C(C1=CNC2=NC=NC(C3=CC=CC(NC(C(C)=C)=O)=C3)=C21)OCC