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JH-II-127

促销

LRRK2 抑制剂

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产品目录号: A15777

库存状态:中国现货中国现货

产品名 目录号 价格 数量
JH-II-127 5mg A15777-5
¥ 1,200.00
JH-II-127 10mg A15777-10
¥ 2,000.00
JH-II-127 25mg A15777-25
¥ 4,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.

JH-II-127

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Chemical Information

目录号 A15777
Mechanism of action Inhibitor
分子量 416.86
化学分子式 C19H21ClN6O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1700693-08-8
Synonyms N/A
SMILES code CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC
化学名称 N/A

生物活性

Description
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.94 mL 239.89mL
0.5 mM 4.8 mL 23.99 mL 47.98 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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