JIB-04
JIB-04 是一种广谱选择性的 Jumonji 组蛋白去甲基化酶抑制剂，其半抑制浓度（IC50）分别为 JARID1A 230 nM、JMJD2E 340 nM、JMJD3 855 nM、JMJD2A 445 nM、JMJD2B 435 nM、JMJD2C 1100 nM 和 JMJD2D 290 nM。
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生物活性
| Discription | JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
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产品信息
| 目录号 | A13806 |
|---|---|
| 分子式 | C17H13ClN4 |
| 分子量 | 308.76 |
| CAS号 | 199596-05-9 |
| SMILES | C1=CC=C(C=C1)/C(=N\NC2=NC=C(C=C2)Cl)/C3=CC=CC=N3 |
| 其他名称 | NSC 693627, JIB04 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | Warmed: 22 mg/mL (71.24 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+corn oil | 2 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.39 mL | 161.94 mL | 323.88 mL |
| 0.5 mM | 6.48 mL | 32.39 mL | 64.78 mL |
| 1 mM | 3.24 mL | 16.19 mL | 32.39 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 JIB-04 | JIB-04 供应商 | JIB-04 花费 | JIB-04 生产商 | 订购 JIB-04 | JIB-04 代理商
| 购买 199596-05-9 | 199596-05-9 供应商 | 199596-05-9 花费 | 199596-05-9 生产商 | 订购 199596-05-9 | 199596-05-9 代理商