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JNJ-28312141

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CSF1R 抑制剂

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产品目录号: A12687

库存状态:中国现货中国现货

产品名 目录号 价格 数量
JNJ-28312141 5mg A12687-5
¥ 3,500.00
JNJ-28312141 10mg A12687-10
¥ 6,500.00
JNJ-28312141 25mg A12687-25
¥ 12,000.00
JNJ-28312141 50mg A12687-50
¥ 20,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.

JNJ-28312141

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Chemical Information

目录号 A12687
Mechanism of action Inhibitor
分子量 460.57
化学分子式 C26H32N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 885692-52-4
Synonyms JNJ 28312141, JNJ28312141
SMILES code CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4
化学名称 4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide

生物活性

Description
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.56 mL 217.12mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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