JNJ-28312141

目录号: A12687

CSF1R 抑制剂

JNJ-28312141

JNJ-28312141 Chemical Structure

CAS NO. 885692-52-4

JNJ-28312141是一种口服活性CSF1R抑制剂(Colony-stimulating factor-1受体,CRF1R),也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达,是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。

库存: 现货

规格 价格 数量
5 mg
¥ 3,500.00
10 mg
¥ 6,500.00
25 mg
¥ 12,000.00
50 mg
¥ 20,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

JNJ-28312141是一种口服活性CSF1R抑制剂(Colony-stimulating factor-1受体,CRF1R),也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达,是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.56 mL 217.12 mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12687
作用机制 Inhibitor (抑制剂)
M. Wt 460.57
Formula C26H32N6O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 885692-52-4
Synonyms JNJ 28312141, JNJ28312141
SMILES CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4

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