JNJ-54175446
目录号: A18675
P2X7 receptor 拮抗剂
JNJ-54175446 是一种强效且选择性的能穿透大脑的 P2X7 受体拮抗剂,对人类P2X7受体(hP2X7 receptor)和大鼠P2X7受体(rP2X7 receptor)的 pIC50 分别为 8.46 和 8.81。
Discription | JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
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目录号 | A18675 |
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分子式 | C18H13ClF4N6O |
分子量 | 440.78 |
CAS号 | 1627902-21-9 |
SMILES | ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F |
其他名称 | JNJ54175446, JNJ 54175446 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2