JNJ-7706621

目录号: A10494

CDK/Aurora A/B Inhibitor

JNJ-7706621

JNJ-7706621 Chemical Structure

CAS NO. 443797-96-4

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 2,100.00
50 mg
¥ 5,000.00
100 mg
¥ 8,600.00
10mM * 1mL in DMSO
¥ 1,540.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
In vitro (25°C) DMSO 79 mg/mL (200.32 mM)
Water <1 mg/mL (<1 mM
Ethanol <1 mg/mL (<1 mM
In vivo 0.5% methylcellulose/0.2% Tween 80 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.77 mL 253.55 mL
0.5 mM 5.07 mL 25.35 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10494
MECHANISM OF ACTION Inhibitor
M. Wt 394.4
Formula C15H12F2N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 443797-96-4
Synonyms JNJ7706621
SMILES C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F

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