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TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.55 mL | 117.76 mL | 235.52 mL |
| 0.5 mM | 4.71 mL | 23.55 mL | 47.1 mL |
| 1 mM | 2.36 mL | 11.78 mL | 23.55 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
*The above data is based on the productmolecular weight 424.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21846 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 424.6 |
| Formula | C25H32N2O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 145903-06-6 |
| Synonyms | K201 free base, K 201, K-201, JTV 519, JTV519 |
| SMILES | COC1=CC=C2C(CN(C(CCN3CCC(CC4=CC=CC=C4)CC3)=O)CCS2)=C1 |
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