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JW74

Wnt 抑制剂

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产品目录号: A16219

库存状态:中国现货中国现货

产品名 目录号 价格 数量
JW74 5mg A16219-5
¥ 700.00
JW74 10mg A16219-10
¥ 1,000.00
JW74 50mg A16219-50
¥ 3,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

JW74

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 JW74 发表的文献 (1)
  • Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/汕-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152

Chemical Information

目录号 A16219
Mechanism of action Inhibitor
分子量 456.52
化学分子式 C24H20N6O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 863405-60-1
Synonyms JW-74, JW 74
SMILES code CC1=CC=C(C2=NOC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=C(OC)C=C5)=N2)C=C1
化学名称 5-(((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole

生物活性

Description
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.9 mL 109.52 mL 219.05mL
0.5 mM 4.38 mL 21.9 mL 43.81 mL
1 mM 2.19 mL 10.95 mL 21.9 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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