JZL184

Name: JZL184
SKU: A12747
Price: 210 CNY
Rating: 5 (4 reviews)

目录号: A12747

MAGL 抑制剂

4 篇发表文献

JZL184 是一种强效且选择性的单酰基甘油酯脂肪酶（MAGL）抑制剂。在小鼠大脑中体内阻断内源性大麻素2-花生四烯酰甘油（2-AG）的水解作用（IC50 = 8 nM）。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥350.00	现货
25mg	¥770.00	现货
50mg	¥1,400.00	现货
100mg	¥2,660.00	现货
200mg	¥3,710.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用JZL184发表的4篇文献

Lakhan S Khara, .et al. , J Exp Biol, 2022, May 1;225(9):jeb244146 PMID: 35438163

Md Shah Sufian, .et al. , J Exp Biol, 2021, 21 JUNE

Toshihiko Tsutsumi, .et al. , Biochim Biophys Acta Mol Cell Biol Lipids, 2020, Sep;1865(9):158761 PMID: 32629025

Rea Pihlaja, .et al. , Front Neurosci, 2017, 11: 299 PMID: 28611577

生物活性

Discription

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12747
分子式	C27H24N2O9
分子量	520.49
CAS号	1101854-58-3
SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
其他名称	JZL-184, JZL 184
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	86 mg/mL (165.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.21 mL	96.06 mL	192.13 mL
0.5 mM	3.84 mL	19.21 mL	38.43 mL
1 mM	1.92 mL	9.61 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

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