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JZL184

MAGL 抑制剂

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产品目录号: A12747

库存状态:中国现货中国现货

产品名 目录号 价格 数量
JZL184 10mg A12747-10
¥ 400.00
JZL184 25mg A12747-25
¥ 800.00
JZL184 50mg A12747-50
¥ 1,300.00
JZL184 100mg A12747-100
¥ 2,000.00
JZL184 10mM * 1mL in DMSO A12747-10mM-D
¥ 610.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).

JZL184

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 JZL184 发表的文献 (1)
  • Rea Pihlaja, .et al. The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the A汕 Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay, Front Neurosci, 2017, 11: 299 PMID: 28611577

Chemical Information

目录号 A12747
Mechanism of action Inhibitor
分子量 520.49
化学分子式 C27H24N2O9
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1101854-58-3
Synonyms JZL-184, JZL 184
SMILES code C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
化学名称 4-[Bis(1,3-benzodioxol-5-yl)hydroxy?methyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester

生物活性

Description
JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (192.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.21 mL 96.06 mL 192.13mL
0.5 mM 3.84 mL 19.21 mL 38.43 mL
1 mM 1.92 mL 9.61 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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