产品详情

生物活性

K02288是一种有效的选择性I型BMP受体抑制剂，对ALK2，ALK1和ALK6的IC50为1.1、1.8、6.4 nM。

Targets

Target	Value
ALK2	IC50: 1.1nM
ALK1	IC50: 1.8nM
ALK6	IC50: 6.4nM
ALK3	IC50: 34.4nM
ALK4	IC50: 302nM
ALK5	IC50: 321nM

溶解度 *

In vitro	DMSO	67 mg/mL (190.13 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.89 mL	283.78 mL
0.5 mM	5.68 mL	28.38 mL	56.76 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

*The above data is based on the productmolecular weight 352.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14311
作用机制	Inhibitor (抑制剂)
M. Wt	352.38
Formula	C20H20N2O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1431985-92-0
Synonyms	K 02288, K-02288
SMILES	COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N