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CDK 抑制剂

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产品目录号: A15889


产品名 目录号 价格 数量
K03861 5mg A15889-5
¥ 1,400.00
K03861 10mg A15889-10
¥ 2,200.00
K03861 25mg A15889-25
¥ 4,900.00



K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.





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Chemical Information

目录号 A15889
Mechanism of action Inhibitor
分子量 501.5
化学分子式 C24H26F3N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 853299-07-7
Synonyms K 03861, K-03861
SMILES code CN1CCN(CC2=C(C(F)(F)F)C=C(/N=C(O)/NC3=CC=C(OC(C=CN4)=NC4=N)C=C3)C=C2)CC1
化学名称 Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-


K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
CDK2(C118L/A144C) CDK2(A144C) CDK2(C118L) CDK2(WT)
9.7 nM(Kd)15.4 nM(Kd)18.6 nM(Kd)50 nM(Kd)


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.94 mL 99.7 mL 199.4mL
0.5 mM 3.99 mL 19.94 mL 39.88 mL
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL

*The above data is based on the productmolecular weight 501.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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