Keliximab (SB-210396) is a chimeric human/macaque IgG1 monoclonal antibody targeting CD4 with a dissociation constant (Ki) of 1.0 nM for soluble CD4. This antibody effectively blocks T-cell proliferation and inhibits the production of interleukin-2 (IL-2), mechanisms critical in the immune response. Due to its specific action on T-cells, Keliximab is extensively utilized in oncological research to study the modulation of the immune system in the tumor microenvironment.
Keliximab (SB-210396) is a chimeric human/macaque IgG1 monoclonal antibody targeting CD4 with a dissociation constant (Ki) of 1.0 nM for soluble CD4. This antibody effectively blocks T-cell proliferation and inhibits the production of interleukin-2 (IL-2), mechanisms critical in the immune response. Due to its specific action on T-cells, Keliximab is extensively utilized in oncological research to study the modulation of the immune system in the tumor microenvironment.
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