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Ketoconazole

促销

P450 抑制剂

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产品目录号: A10498

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Ketoconazole 100mg A10498-100
¥ 500.00
Ketoconazole 200mg A10498-200
¥ 850.00
Ketoconazole 500mg A10498-500
¥ 1,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes.

Ketoconazole

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Chemical Information

目录号 A10498
Mechanism of action Inhibitor
分子量 531.4
化学分子式 C26H28Cl2N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 65277-42-1
Synonyms Nizoral, Extina, Xolegel, Kuric
SMILES code CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
化学名称 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

生物活性

Description
As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes.
Targets
Cyclosporine oxidase Testosterone 6 beta-hydroxylase
0.19 mM0.22 mM

溶解性

Solubility (25°C) * In vitro DMSO 3 mg/mL (5.64 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (13.17 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.82 mL 94.09 mL 188.18mL
0.5 mM 3.76 mL 18.82 mL 37.64 mL
1 mM 1.88 mL 9.41 mL 18.82 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 531.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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