Ketoconazole

Name: Ketoconazole
SKU: A10498

目录号: A10498

P450 抑制剂

Ketoconazole Chemical Structure

CAS NO. 65277-42-1

ketoconazole作为抗真菌药在结构上类似于咪唑，并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。

库存：现货

规格	价格	数量
100 mg	￥ 500.00
200 mg	￥ 850.00
500 mg	￥ 1,500.00

或

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

ketoconazole作为抗真菌药在结构上类似于咪唑，并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。

靶点信息

Cyclosporine oxidase	Testosterone 6 beta-hydroxylase
0.19 mM	0.22 mM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (9.4 mM)
	Water	Insoluble
	Ethanol	7 mg/mL
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.82 mL	94.09 mL	188.18 mL
0.5 mM	3.76 mL	18.82 mL	37.64 mL
1 mM	1.88 mL	9.41 mL	18.82 mL
5 mM	0.38 mL	1.88 mL	3.76 mL

*The above data is based on the productmolecular weight 531.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10498
作用机制	Inhibitor (抑制剂)
M. Wt	531.4
Formula	C26H28Cl2N4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	65277-42-1
Synonyms	Nizoral, Extina, Xolegel, Kuric
SMILES	CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl