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VEGFR-2 抑制剂

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产品目录号: A10502


产品名 目录号 价格 数量
Ki8751 5mg A10502-5
¥ 500.00
Ki8751 10mg A10502-10
¥ 750.00
Ki8751 50mg A10502-50
¥ 3,000.00
Ki8751 100mg A10502-100
¥ 5,000.00
Ki8751 10mM * 1mL in DMSO A10502-10mM-D
¥ 800.00



Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Ki8751 发表的文献 (1)
  • Kohei Ashina, .et al. VEGF-induced blood flow increase causes vascular hyper-permeability in vivo, Biochem Biophys Res Commun, 2015, Aug 21;464(2):590-5 PMID: 26163262

Chemical Information

目录号 A10502
Mechanism of action Inhibitor
分子量 469.4
化学分子式 C24H18F3N3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 228559-41-9
Synonyms Ki-8751
化学名称 N-(2,4-Difluorophenyl)-N'-[4-[(6,7-d imethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea


Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.
Target Value
VEGFR2IC50: 0.9nM
c-KitIC50: 40nM
PDGFRαIC50: 67nM
FGFR2IC50: 170nM
EGFRIC50: >10μM
HGFRIC50: >10μM
Insulin ReceptorIC50: >10μM


Solubility (25°C)* In vitro DMSO 47 mg/mL (100.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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