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Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.64 mL | 83.18 mL | 166.36 mL |
| 0.5 mM | 3.33 mL | 16.64 mL | 33.27 mL |
| 1 mM | 1.66 mL | 8.32 mL | 16.64 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.33 mL |
*The above data is based on the productmolecular weight 601.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18641 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 601.12 |
| Formula | C31H29ClN6O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1630086-20-2 |
| Synonyms | AMG 18, AMG18 |
| SMILES | O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O |
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