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KN-93 Phosphate

促销

CaMKII 抑制剂

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产品目录号: A14288

库存状态:中国现货中国现货

产品名 目录号 价格 数量
KN-93 Phosphate 10mg A14288-10
¥ 1,100.00
KN-93 Phosphate 25mg A14288-25
¥ 2,200.00
KN-93 Phosphate 50mg A14288-50
¥ 4,000.00
KN-93 Phosphate 10mM * 1mL in DMSO A14288-10mM-D
¥ 1,250.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.

KN-93 Phosphate

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 KN-93 Phosphate 发表的文献 (1)
  • Kazuki Yuasa, .et al. Targeted ablation of p38汐 MAPK suppresses denervation-induced muscle atrophy, Sci Rep, 2018, 8: 9037 PMID: 29899565

Chemical Information

目录号 A14288
Mechanism of action Inhibitor
分子量 599.03
化学分子式 C26H29ClN2O4S. H3O4P
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1188890-41-6
Synonyms KN93, KN 93
SMILES code [HH].CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OOP(=O)=O
化学名称 Benzenesulfonamide, N-?[2-?[[[(2E)?-?3-?(4-?chlorophenyl)?-?2-?propen-?1-?yl]?methylamino]?methyl]?phenyl]?-?N-?(2-?hydroxyethyl)?-?4-?methoxy-?, phosphate (1:1)

生物活性

Description
KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
Targets
CaMKII
0.37 μM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (166.93 mM)
Water 92 mg/mL (153.58 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.69 mL 83.47 mL 166.94mL
0.5 mM 3.34 mL 16.69 mL 33.39 mL
1 mM 1.67 mL 8.35 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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