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KNK437剂量依赖性地抑制了COLO 320DM（人类结肠癌）细胞中耐热性的获得以及各种HSP的诱导，包括HSP105，HSP70和HSP40。
靶点信息
| HSP105 | HSP72 | HSP40 | ||
| In vitro (25°C) | DMSO | Warmed: 14 mg/mL (57.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+corn oil | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.78 mL | 203.89 mL | 407.78 mL |
| 0.5 mM | 8.16 mL | 40.78 mL | 81.56 mL |
| 1 mM | 4.08 mL | 20.39 mL | 40.78 mL |
| 5 mM | 0.82 mL | 4.08 mL | 8.16 mL |
*The above data is based on the productmolecular weight 245.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14389 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 245.23 |
| Formula | C13H11NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 218924-25-5 |
| Synonyms | KNK-437, KNK 437 |
| SMILES | O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O |
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