Selinexor (KPT-330)

Name: Selinexor (KPT-330)
SKU: A12582
Price: 210 CNY
Rating: 5 (2 reviews)

目录号: A12582

CRM1 抑制剂

2 篇发表文献

KPT-330 抑制剂针对 CRM1 (XPO1) 介导的核输出具有选择性抗白血病活性，在T细胞急性淋巴细胞性白血病和急性髓性白血病的临床前模型中表现出效果。

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Grouped product items
规格	价格	库存
2mg	¥210.00	现货
5mg	¥385.00	现货
10mg	¥665.00	现货
25mg	¥1,365.00	现货
50mg	¥2,415.00	现货
100mg	¥3,325.00	现货
*10mM 1mL in DMSO**	¥784.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Selinexor (KPT-330)发表的2篇文献

Youjin Na, .et al. , Oncogene, 2023, Mar;42(13):1038-1047 PMID: 36759572

Chie Ishikawa, .et al. , Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814

生物活性

Discription

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Targets

Target	Value

产品信息

目录号	A12582
分子式	C17H11F6N7O
分子量	443.31
CAS号	1393477-72-9
SMILES	C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
其他名称	KPT330, KPT 330
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	78 mg/mL (175.94 mM)
	Water	Insoluble
	Ethanol	36 mg/mL (81.21 mM)
In vivo	2% DMSO+40%PEG 300+5% Tween80 +ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.79 mL	225.58 mL
0.5 mM	4.51 mL	22.56 mL	45.12 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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