产品详情

生物活性

KPT185是选择性CRM1抑制剂。KPT-185以100 nM至500 nM的IC50显着抑制白血病细胞增殖，并诱导AML细胞系和原发性AML原始细胞的细胞周期停滞和凋亡。

靶点信息

CRM1

溶解度 *

In vitro	DMSO	60 mg/mL (168.86 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (168.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.14 mL	140.72 mL	281.44 mL
0.5 mM	5.63 mL	28.14 mL	56.29 mL
1 mM	2.81 mL	14.07 mL	28.14 mL
5 mM	0.56 mL	2.81 mL	5.63 mL

*The above data is based on the productmolecular weight 355.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12975
作用机制	Inhibitor (抑制剂)
M. Wt	355.31
Formula	C16H16F3N3O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1333151-73-7
Synonyms	KPT 185, KPT-185
SMILES	CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F