KPT185

Name: KPT185
SKU: A12975
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A12975

CRM1 抑制剂

KPT185 是一种选择性的 CRM1 抑制剂。KPT-185 显著抑制白血病细胞增殖，IC50 范围从 100 nM 到 500 nM，并诱导 AML 细胞系和原发性 AML 爆发细胞的细胞周期阻滞和凋亡。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥385.00	现货
10mg	¥420.00	现货
25mg	¥665.00	现货
50mg	¥1,260.00	现货
100mg	¥2,205.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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Data Sheet

SDS

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生物活性

Discription

KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.

Targets

Target	Value

产品信息

目录号	A12975
分子式	C16H16F3N3O3
分子量	355.31
CAS号	1333151-73-7
SMILES	CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
其他名称	KPT 185, KPT-185
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	60 mg/mL (168.86 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (168.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.14 mL	140.72 mL	281.44 mL
0.5 mM	5.63 mL	28.14 mL	56.29 mL
1 mM	2.81 mL	14.07 mL	28.14 mL
5 mM	0.56 mL	2.81 mL	5.63 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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