KRN 633

目录号: A10504

VEGFR Inhibitor

KRN 633 Chemical Structure

CAS NO. 286370-15-8

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).

库存: 现货

规格 价格 数量
5 mg
¥ 800.00
10 mg
¥ 1,400.00
50 mg
¥ 3,400.00
100 mg
¥ 5,400.00
10mM * 1mL in DMSO
¥ 900.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
Targets
Target Value
VEGFR3IC50: 125nM
VEGFR2IC50: 160nM
VEGFR1IC50: 170nM
PDGFRαIC50: 965nM
c-KitIC50: 4330nM
BTKIC50: 9200nM
PDGFRβIC50: 9850nM
Tie-2IC50: 9900nM
In vitro (25°C) DMSO 9 mg/mL (21.58 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.93 mL 239.87 mL
0.5 mM 4.8 mL 23.99 mL 47.97 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10504
MECHANISM OF ACTION Inhibitor
M. Wt 416.9
Formula C20H21ClN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 286370-15-8
Synonyms KRN633, KRN-633
SMILES CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl

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