KU-55933

Name: KU-55933
SKU: A10506

目录号: A10506

ATM 抑制剂

Product Citations (4)

KU-55933 Chemical Structure

CAS NO. 587871-26-9

KU-55933是ATM抑制剂，通过抑制细胞增殖，并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
10 mg	￥ 600.00
50 mg	￥ 2,000.00
100 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 600.00

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生物活性

KU-55933是ATM抑制剂，通过抑制细胞增殖，并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。

Targets

Target	Value
ATM	IC50: 12.9nM
DNA-PK	IC50: 2.5μM
mTOR	IC50: 9.3μM
PI3K	IC50: 16.6μM
ATR	IC50: >100μM
PI4K	IC50: >100μM

溶解度 *

In vitro (25°C)	DMSO	29 mg/mL (73.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	3.75 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.28 mL	126.42 mL	252.84 mL
0.5 mM	5.06 mL	25.28 mL	50.57 mL
1 mM	2.53 mL	12.64 mL	25.28 mL
5 mM	0.51 mL	2.53 mL	5.06 mL

*The above data is based on the productmolecular weight 395.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10506
作用机制	Inhibitor (抑制剂)
M. Wt	395.5
Formula	C21H17NO3S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	587871-26-9
Synonyms	KU55933
SMILES	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4