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ATM 抑制剂

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产品目录号: A10506


产品名 目录号 价格 数量
KU-55933 5mg A10506-5
¥ 400.00
KU-55933 10mg A10506-10
¥ 600.00
KU-55933 50mg A10506-50
¥ 2,000.00
KU-55933 100mg A10506-100
¥ 3,500.00
KU-55933 10mM * 1mL in DMSO A10506-10mM-D
¥ 600.00



KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 KU-55933 发表的文献 (2)
  • Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732
  • Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a 污H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201

Chemical Information

目录号 A10506
Mechanism of action Inhibitor
分子量 395.5
化学分子式 C21H17NO3S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 587871-26-9
Synonyms KU55933
化学名称 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one


KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
Target Value
ATMIC50: 12.9nM
DNA-PKIC50: 2.5μM
mTORIC50: 9.3μM
PI3KIC50: 16.6μM
ATRIC50: >100μM
PI4KIC50: >100μM


Solubility (25°C) * In vitro DMSO 33 mg/mL (83.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO and 47.5% PEG300 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.28 mL 126.42 mL 252.84mL
0.5 mM 5.06 mL 25.28 mL 50.57 mL
1 mM 2.53 mL 12.64 mL 25.28 mL
5 mM 0.51 mL 2.53 mL 5.06 mL

*The above data is based on the productmolecular weight 395.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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