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FLT3/FGFR/Bcr-Abl/Aurora 抑制剂

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产品目录号: A10508


产品名 目录号 价格 数量
KW-2449 10mg A10508-10
¥ 500.00
KW-2449 50mg A10508-50
¥ 2,200.00
KW-2449 100mg A10508-100
¥ 4,000.00
KW-2449 200mg A10508-200
¥ 6,800.00
KW-2449 10mM * 1mL in DMSO A10508-10mM-D
¥ 760.00



KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10508
Mechanism of action Inhibitor
分子量 332.4


Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1000669-72-6
Synonyms KW 2449, KW2449
SMILES code C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43
化学名称 [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone


KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM


Solubility (25°C) * In vitro DMSO 67 mg/mL (201.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (201.56 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.08 mL 150.42 mL 300.84mL
0.5 mM 6.02 mL 30.08 mL 60.17 mL
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL

*The above data is based on the productmolecular weight 332.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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