Lanadelumab (SHP643) is a human IgG1 monoclonal antibody specifically targeting plasma kallikrein (pKal), exhibiting a potent inhibitory constant (Ki) of 0.12 nM. This antibody is capable of inhibiting both free and high molecular weight kininogen (HMWK)-bound forms of pKal. Lanadelumab is primarily utilized in research focused on hereditary angioedema, offering significant potential for elucidating the pathophysiology and therapeutic targeting of this condition.
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody specifically targeting plasma kallikrein (pKal), exhibiting a potent inhibitory constant (Ki) of 0.12 nM. This antibody is capable of inhibiting both free and high molecular weight kininogen (HMWK)-bound forms of pKal. Lanadelumab is primarily utilized in research focused on hereditary angioedema, offering significant potential for elucidating the pathophysiology and therapeutic targeting of this condition.
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