Latozinemab (AL001) is a recombinant human monoclonal antibody targeting Sortilin. It binds with high affinity to Sortilin, effectively inhibiting the interaction between the progranulin protein (PGRN) and the Sortilin receptor. This antibody is particularly relevant for research into mutations in the progranulin gene (GRN) that are implicated in the pathogenesis of Frontotemporal Dementia (FTD-GRN), offering potential insights into therapeutic interventions and disease mechanisms.
Latozinemab (AL001) is a recombinant human monoclonal antibody targeting Sortilin. It binds with high affinity to Sortilin, effectively inhibiting the interaction between the progranulin protein (PGRN) and the Sortilin receptor. This antibody is particularly relevant for research into mutations in the progranulin gene (GRN) that are implicated in the pathogenesis of Frontotemporal Dementia (FTD-GRN), offering potential insights into therapeutic interventions and disease mechanisms.
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