LBH589 (Panobinostat)

Name: LBH589 (Panobinostat)
SKU: A10518
Price: 175 CNY
Rating: 5 (5 reviews)

目录号: A10518

HDAC 抑制剂

5 篇发表文献

LBH589 是一种羟胺酸，作为非选择性 HDAC 抑制剂，其对 HDAC1 的 IC50 为 0.23 nM。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
25mg	¥490.00	现货
50mg	¥700.00	现货
100mg	¥980.00	现货
200mg	¥1,260.00	现货
500mg	¥2,625.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LBH589 (Panobinostat)发表的5篇文献

Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871

Gils Jose, .et al. , Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721

Shariful Islam, .et al. , Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458

Giovanni Bocci, .et al. , ACS Pharmacol Transl Sci, 2020, Oct 14

Justin Kale, .et al. , EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135

生物活性

Discription

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10518
分子式	C21H23N3O2
分子量	349.4
CAS号	404950-80-7
SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
其他名称	NVP-LBH589
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	60 mg/mL (171.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+48% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.1 mL	286.2 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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