- Justin Kale, .et al. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance, EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135
|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.|
|Solubility (25°C) *||In vitro||DMSO||69 mg/mL (197.46 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||2% DMSO, 2% Tween 80, 48% PEG 300||5|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||28.62 mL||143.1 mL||286.2mL|
|0.5 mM||5.72 mL||28.62 mL||57.24 mL|
|1 mM||2.86 mL||14.31 mL||28.62 mL|
|5 mM||0.57 mL||2.86 mL||5.72 mL|
*The above data is based on the productmolecular weight 349.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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