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LBH589 (Panobinostat)


HDAC 抑制剂

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产品目录号: A10518


产品名 目录号 价格 数量
LBH589 10mg A10518-10
¥ 500.00
LBH589 50mg A10518-50
¥ 1,100.00
LBH589 100mg A10518-100
¥ 1,500.00
LBH589 200mg A10518-200
¥ 2,500.00
LBH589 (Panobinostat) 10mM * 1mL in DMSO A10518-10mM-D
¥ 600.00



LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.

LBH589 (Panobinostat)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LBH589 (Panobinostat) 发表的文献 (1)
  • Justin Kale, .et al. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance, EMBO Rep, 2018, Sep; 19(9): e45235 PMID: 29987135

Chemical Information

目录号 A10518
Mechanism of action Inhibitor
分子量 349.4
化学分子式 C21H23N3O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 404950-80-7
Synonyms NVP-LBH589, LBH-589
化学名称 (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide


LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
HDAC (MOLT-4 cells) HDAC (Reh cells)
5 nM20 nM


Solubility (25°C) * In vitro DMSO 69 mg/mL (197.46 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% DMSO, 2% Tween 80, 48% PEG 300 5
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.62 mL 143.1 mL 286.2mL
0.5 mM 5.72 mL 28.62 mL 57.24 mL
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL

*The above data is based on the productmolecular weight 349.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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