Trusted by 10,000+ Scientists since 2006



拮抗剂 of IAPs 抑制剂

0 Customer Reviews
产品目录号: A11928


产品名 目录号 价格 数量
LCL-161 5mg A11928-5
¥ 600.00
LCL-161 10mg A11928-10
¥ 1,000.00
LCL-161 25mg A11928-25
¥ 1,800.00
LCL-161 10mM * 1mL in DMSO A11928-10mM-D
¥ 1,190.00



LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LCL-161 发表的文献 (4)
  • Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
  • Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
  • Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707每725 PMID: 25952668
  • Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Chemical Information

目录号 A11928
Mechanism of action Antagonist
分子量 500.2
化学分子式 C26H33FN4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1005342-46-0
Synonyms LCL161, LCL 161
SMILES code C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
化学名称 (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide


LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.


Solubility (25°C)* In vitro DMSO 100 mg/mL (199.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL heating (39.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.96 mL 199.92mL
0.5 mM 4 mL 19.99 mL 39.98 mL
1 mM 2 mL 10 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Cat. No.

Product NameSolubility(mg/mL)
A10255ABT-737<1 mg/mL163 mg/mL<1 mg/mL
A10022ABT-263 (Navitoclax)<1 mg/mL195 mg/mL<1 mg/mL
A10665Obatoclax mesylate (GX15-070)<1 mg/mL83 mg/mL<1 mg/mL
A10955TW-37<1 mg/mL115 mg/mL4 mg/mL
A10984VX-765<1 mg/mL102 mg/mL102 mg/mL
A11090PAC-1<1 mg/mL78 mg/mL16 mg/mL
A10491JNJ 26854165<1 mg/mL66 mg/mL2 mg/mL
A11931RITA (NSC 652287)<1 mg/mL115 mg/mL4 mg/mL
A10522Lenalidomide (CC-5013)<1 mg/mL52 mg/mL<1 mg/mL
A10743Pomalidomide (CC-4047)<1 mg/mL55 mg/mL<1 mg/mL
A11163AT-406<1 mg/mL112 mg/mL112 mg/mL
A11002YM15589 mg/mL55 mg/mL6 mg/mL
A10935Tipifarnib (Zarnestra)<1 mg/mL83 mg/mL<1 mg/mL
A10657Nutlin-3<1 mg/mL116 mg/mL116 mg/mL

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.




Similar product(s)

Keywords:购买 LCL-161 | LCL-161 供应商 | 订购 LCL-161 | LCL-161 价格 | LCL-161 生产商 | 订单 LCL-161 | LCL-161 代理商 | 购买 1005342-46-0| 1005342-46-0 供应商 | 订购 1005342-46-0 | 1005342-46-0 价格 | 1005342-46-0 生产商 | 订单 1005342-46-0 | 1005342-46-0 代理商|buy LCL-161 | LCL-161 Supplier | purchase LCL-161 | LCL-161 cost | LCL-161 manufacturer | order LCL-161 | LCL-161 distributor | buy 1005342-46-0| 1005342-46-0 Supplier | purchase 1005342-46-0 | 1005342-46-0 cost | 1005342-46-0 manufacturer | order 1005342-46-0 | 1005342-46-0 distributor