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LCL-161

促销

拮抗剂 of IAPs 抑制剂

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产品目录号: A11928

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LCL-161 5mg A11928-5
¥ 600.00
LCL-161 10mg A11928-10
¥ 1,000.00
LCL-161 25mg A11928-25
¥ 1,800.00
LCL-161 10mM * 1mL in DMSO A11928-10mM-D
¥ 1,190.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

LCL-161

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LCL-161 发表的文献 (4)
  • Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
  • Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
  • Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707每725 PMID: 25952668
  • Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Chemical Information

目录号 A11928
Mechanism of action Antagonist
分子量 500.2
化学分子式 C26H33FN4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1005342-46-0
Synonyms LCL161, LCL 161
SMILES code C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
化学名称 (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide

生物活性

Description
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
Targets
cIAP XIAP

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (199.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL heating (39.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.96 mL 199.92mL
0.5 mM 4 mL 19.99 mL 39.98 mL
1 mM 2 mL 10 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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