LCL-161

Name: LCL-161
SKU: A11928
Price: 385 CNY
Rating: 5 (9 reviews)

目录号: A11928

Ant激动剂 of IAPs 抑制剂

9 篇发表文献

LCL161 是一种口服生物利用度的第二线线粒体来源的半胱天冬酶激活剂（SMAC）模拟物和 IAP（抑制凋亡蛋白） 家族蛋白的抑制剂，具有潜在的抗肿瘤活性。

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Grouped product items
规格	价格	库存
2mg	¥385.00	现货
5mg	¥525.00	现货
10mg	¥665.00	现货
25mg	¥1,225.00	现货
50mg	¥2,030.00	现货
100mg	¥3,290.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LCL-161发表的9篇文献

Oliver H, .et al. , J Med Chem, 2023, 66, 16, 11216-11236 PMID: 37535857

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

Han-Hee Park, .et al. , Mol Cancer, 2021, Aug 21;20(1):107 PMID: 34419074

Se-Yeon Park, .et al. , Cell Death & Disease, 2020, 11:744 PMID: 32917855

J Chen, .et al. , JBC, 2019, June PMID: 31217278

Choi SW, .et al. , Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609

Han-Hee Park, .et al. , Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400

Gi-Bang Koo, .et al. , Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668

Kim SK, .et al. , J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

生物活性

Discription

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11928
分子式	C26H33FN4O3S
分子量	500.2
CAS号	1005342-46-0
SMILES	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
其他名称	LCL161, LCL 161
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	86 mg/mL (171.78 mM)
	Water	Insoluble
	Ethanol	Warmed: 17 mg/mL (33.95 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.99 mL	99.96 mL	199.92 mL
0.5 mM	4 mL	19.99 mL	39.98 mL
1 mM	2 mL	10 mL	19.99 mL
5 mM	0.4 mL	2 mL	4 mL

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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