LCZ696 (Valsartan)
目录号: A14206
angiotensin receptor-neprilysin 抑制剂
LCZ696 是一种口服生物利用度高的双重作用药物,它是血管紧张素受体-肽酶抑制剂(ARNi),用于治疗高血压和心力衰竭。
Discription | LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. | ||
---|---|---|---|
Targets |
|
目录号 | A14206 |
---|---|
分子式 | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
分子量 | 915.98 |
CAS号 | 936623-90-4 |
SMILES | CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O.CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.O.O.O.[Na+].[Na+].[Na+] |
其他名称 | LCZ 696, LCZ-696 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | Warmed: 26 mg/mL (28.38 mM) | |
Water | Warmed: 88 mg/mL (96.07 mM) | ||
Ethanol | Warmed: 8 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 10.92 mL | 54.59 mL | 109.17 mL |
0.5 mM | 2.18 mL | 10.92 mL | 21.83 mL |
1 mM | 1.09 mL | 5.46 mL | 10.92 mL |
5 mM | 0.22 mL | 1.09 mL | 2.18 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2