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LDC000067

CDK 抑制剂

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产品目录号: A14273

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LDC000067 10mg A14273-10
¥ 800.00
LDC000067 25mg A14273-25
¥ 1,600.00
LDC000067 50mg A14273-50
¥ 2,800.00
LDC000067 10mM * 1mL in DMSO A14273-10mM-D
¥ 890.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LDC000067 is a highly selective CDK9 inhibitor .

LDC000067

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Chemical Information

目录号 A14273
Mechanism of action Inhibitor
分子量 370.43
化学分子式 C18H18N4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1073485-20-7
Synonyms LDC067
SMILES code COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N
化学名称 3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide

生物活性

Description
LDC000067 is a highly selective CDK9 inhibitor .
Targets
Target Value
CDK9IC50: 44nM
CDK2IC50: 2.441μM
CDK1IC50: 5.513μM
CDK4IC50: 9.242μM
CDK6IC50: >10μM
CDK7IC50: >10μM

溶解性

Solubility (25°C)* In vitro DMSO 74 mg/mL (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27 mL 134.98 mL 269.96mL
0.5 mM 5.4 mL 27 mL 53.99 mL
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL

*The above data is based on the productmolecular weight 370.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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