LDE225 (NVP-LDE225, Sonidegib)

目录号: A10520

Smo Antagonist

LDE225 (NVP-LDE225, Sonidegib)

LDE225 (NVP-LDE225, Sonidegib) Chemical Structure

CAS NO. 956697-53-3

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
50 mg
¥ 1,500.00
100 mg
¥ 2,500.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
Targets
Smo (mouse) (Cell-free assay) Smo (human) (Cell-free assay)
1.3 nM2.5 nM
In vitro (25°C) DMSO 97 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 97 mg/mL (199.79 mM)
In vivo 0.5% CMC 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.6 mL 102.99 mL 205.97 mL
0.5 mM 4.12 mL 20.6 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10520
MECHANISM OF ACTION Antagonist
M. Wt 485.5
Formula C26H26F3N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 956697-53-3
Synonyms LDE-225
SMILES C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

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