Ceritinib (LDK-378)

Name: Ceritinib (LDK-378)
SKU: A13238
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A13238

ALK 抑制剂

LDK378 是一种高度选择性的、口服生物利用度高的、与 ATP 竞争的小分子抑制剂，针对 ALK (间变性淋巴瘤激酶)，这是一种受体酪氨酸激酶，被认为是重要的肺癌药物靶标。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥385.00	现货
50mg	¥595.00	现货
100mg	¥910.00	现货
200mg	¥1,785.00	现货
500mg	¥3,430.00	现货
1g	¥5,740.00	现货
2g	¥9,205.00	现货
5g	¥18,445.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13238
分子式	C28H36ClN5O3S
分子量	558.14
CAS号	1032900-25-6
SMILES	CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
其他名称	LDK378,LDK 378
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 18 mg/mL (32.25 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.37 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.92 mL	89.58 mL	179.17 mL
0.5 mM	3.58 mL	17.92 mL	35.83 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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