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LDK378 (Ceritinib) dihydrochloride

LDK378 (Ceritinib) dihydrochloride

Name: LDK378 (Ceritinib) dihydrochloride
SKU: A15142

目录号: A15142

ALK 抑制剂

LDK378 (Ceritinib) dihydrochloride Chemical Structure

CAS NO. 1380575-43-8

LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。

库存：现货

规格	价格	数量
5 mg	￥ 500.00
10 mg	￥ 700.00
50 mg	￥ 1,000.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.82 mL	84.09 mL	168.18 mL
0.5 mM	3.36 mL	16.82 mL	33.64 mL
1 mM	1.68 mL	8.41 mL	16.82 mL
5 mM	0.34 mL	1.68 mL	3.36 mL

*The above data is based on the productmolecular weight 594.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15142
作用机制	Inhibitor (抑制剂)
M. Wt	594.6
Formula	C28H37Cl2N5O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1380575-43-8
Synonyms	LDK 378 dihydrochloride, LDK-378 dihydrochloride, Ceritinib dihydrochloride
SMILES	CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl.Cl.Cl