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LEE011 (Ribociclib)


CDK4/6 抑制剂

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产品目录号: A13549


产品名 目录号 价格 数量
LEE011 10mg A13549-10
¥ 800.00
LEE011 25mg A13549-25
¥ 1,200.00
LEE011 50mg A13549-50
¥ 1,500.00



LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 (Ribociclib)




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Chemical Information

目录号 A13549
Mechanism of action Inhibitor
分子量 434.54
化学分子式 C23H30N8O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1211441-98-3
Synonyms LEE-011, LEE 011
化学名称 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide


LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CDK4 (Cell-free assay) CDK6 (Cell-free assay)


Solubility (25°C)* In vitro DMSO 7 mg/mL (16.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.06 mL 230.13mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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