LEE011 (Ribociclib)

目录号: A13549

CDK4/6 inhibitor

LEE011 (Ribociclib) Chemical Structure

CAS NO. 1211441-98-3

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

库存: 现货

规格 价格 数量
10 mg
¥ 800.00
25 mg
¥ 1,200.00
50 mg
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
Targets
CDK4 (Cell-free assay) CDK6 (Cell-free assay)
In vitro DMSO 7 mg/mL (16.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.06 mL 230.13 mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13549
MECHANISM OF ACTION Inhibitor
M. Wt 434.54
Formula C23H30N8O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1211441-98-3
Synonyms LEE-011, LEE 011
SMILES CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

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