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Leniolisib (CDZ 173)是一种有效的、选择性的PI3Kδ抑制剂，对PI3Kα、PI3Kβ、PI3Kγ和PI3Kδ的生化IC50值分别为0.244、0.424、2.23和0.011 uM。
| In vitro | DMSO | 81 mg/mL (179.81 mM) | |
| Water | Insoluble | ||
| Ethanol | 12 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.2 mL | 111 mL | 222 mL |
| 0.5 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 1 mM | 2.22 mL | 11.1 mL | 22.2 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16796 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 450.46 |
| Formula | C21H25F3N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1354690-24-6 |
| Synonyms | Leniolisib; CDZ-173; CDZ 173; CDZ173; Leniosilib |
| SMILES | FC(C1=C(OC)N=CC(N(CCC2=NC=N3)CC2=C3N[C@@H]4CN(C(CC)=O)CC4)=C1)(F)F |
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