Leptomycin B

Name: Leptomycin B
SKU: A20985

目录号: A20985

nuclear export receptor CRM1 inhibitor

Leptomycin B Chemical Structure

CAS NO. 87081-35-4

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.

库存：现货

规格	价格	数量
1 mg	￥ 3,200.00
5 mg	￥ 9,600.00
10 mg	￥ 16,000.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.49 mL	92.47 mL	184.94 mL
0.5 mM	3.7 mL	18.49 mL	36.99 mL
1 mM	1.85 mL	9.25 mL	18.49 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 540.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A20985
作用机制	Inhibitor (抑制剂)
M. Wt	540.73
Formula	C33H48O6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	87081-35-4
Synonyms	CI 940, CI940, CI-940; LMB
SMILES	O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(CC)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O