Leronlimab (PRO 140) is a humanized IgG4 monoclonal antibody targeting CCR5, a critical receptor involved in the entry of HIV-1 into cells and in the mediation of inflammatory processes. This antibody effectively inhibits HIV-1 viral entry and has demonstrated potential in reducing lung metastasis in mouse tumor models. Leronlimab is applicable for research in various fields including HIV, nonalcoholic steatohepatitis (NASH), and cancer, providing a versatile tool for investigating the role of CCR5 in disease progression and therapy.
Leronlimab (PRO 140) is a humanized IgG4 monoclonal antibody targeting CCR5, a critical receptor involved in the entry of HIV-1 into cells and in the mediation of inflammatory processes. This antibody effectively inhibits HIV-1 viral entry and has demonstrated potential in reducing lung metastasis in mouse tumor models. Leronlimab is applicable for research in various fields including HIV, nonalcoholic steatohepatitis (NASH), and cancer, providing a versatile tool for investigating the role of CCR5 in disease progression and therapy.
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