Letaplimab (IBI-188) is a human IgG4 monoclonal antibody targeting CD47, a protein frequently overexpressed on the surface of cancer cells and acting as a ligand for signal regulatory protein alpha (SIRP??). By binding to CD47, Letaplimab disrupts its interaction with SIRP??, thereby enhancing the phagocytosis of tumor cells. This mechanism positions Letaplimab as a promising therapeutic agent in the field of oncology, particularly for the treatment of cancers characterized by high CD47 expression.
Letaplimab (IBI-188) is a human IgG4 monoclonal antibody targeting CD47, a protein frequently overexpressed on the surface of cancer cells and acting as a ligand for signal regulatory protein alpha (SIRP??). By binding to CD47, Letaplimab disrupts its interaction with SIRP??, thereby enhancing the phagocytosis of tumor cells. This mechanism positions Letaplimab as a promising therapeutic agent in the field of oncology, particularly for the treatment of cancers characterized by high CD47 expression.
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