Letolizumab (BMS-986004) is a monoclonal antibody engineered to specifically target CD40L. This antibody variant is designed as a mutant IgG1 isotype that lacks effector functions, notably Fc receptor binding and complement fixation capabilities. The primary therapeutic action of Letolizumab is to mitigate rejection and thromboembolism, effectively extending survival time in clinical settings. This makes it particularly valuable in research focused on immune response modulation and transplantation immunology.
Letolizumab (BMS-986004) is a monoclonal antibody engineered to specifically target CD40L. This antibody variant is designed as a mutant IgG1 isotype that lacks effector functions, notably Fc receptor binding and complement fixation capabilities. The primary therapeutic action of Letolizumab is to mitigate rejection and thromboembolism, effectively extending survival time in clinical settings. This makes it particularly valuable in research focused on immune response modulation and transplantation immunology.
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