LGK-974

目录号: A12816

PORCN inhibitor

LGK-974 Chemical Structure

CAS NO. 1243244-14-5

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
50 mg
¥ 5,500.00
10mM * 1mL in DMSO
¥ 1,860.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
靶点信息
Porcn (TM3 cells)
In vitro DMSO 79 mg/mL heating (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.22 mL 126.12 mL 252.24 mL
0.5 mM 5.04 mL 25.22 mL 50.45 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12816
MECHANISM OF ACTION Inhibitor
M. Wt 396.44
Formula C23H20N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1243244-14-5
Synonyms LGK974, LGK 974
SMILES CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C

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