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LGK-974

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PORCN 抑制剂

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产品目录号: A12816

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LGK-974 5mg A12816-5
¥ 900.00
LGK-974 10mg A12816-10
¥ 1,500.00
LGK-974 25mg A12816-25
¥ 3,000.00
LGK-974 50mg A12816-50
¥ 5,500.00
LGK-974 10mM * 1mL in DMSO A12816-10mM-D
¥ 1,860.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.

LGK-974

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LGK-974 发表的文献 (2)
  • Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/汕-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
  • E Lemieux, .et al. Oncogenic KRAS signalling promotes the Wnt/汕-catenin pathway through LRP6 in colorectal cancer, Oncogene, 2015, Sep 17; 34(38): 4914每4927 PMID: 25500543

Chemical Information

目录号 A12816
Mechanism of action Inhibitor
分子量 396.44
化学分子式 C23H20N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1243244-14-5
Synonyms LGK974, LGK 974
SMILES code CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
化学名称 2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

生物活性

Description
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
Targets
Porcn (TM3 cells)

溶解性

Solubility (25°C)* In vitro DMSO 79 mg/mL heating (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.22 mL 126.12 mL 252.24mL
0.5 mM 5.04 mL 25.22 mL 50.45 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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