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LGX 818 (Encorafenib)

Selective B-RAF 抑制剂

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产品目录号: A13226

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LGX 818 1mg A13226-1
¥ 900.00
LGX 818 5mg A13226-5
¥ 3,500.00
LGX 818 10mg A13226-10
¥ 5,500.00
LGX 818 25mg A13226-25
¥ 10,000.00
LGX 818 10mM * 1mL in DMSO A13226-10mM-D
¥ 4,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.

LGX 818 (Encorafenib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LGX 818 (Encorafenib) 发表的文献 (1)
  • Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Chemical Information

目录号 A13226
Mechanism of action Inhibitor
分子量 540.01
化学分子式 C22H27ClFN7O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1269440-17-6, 1269440-29-0
Synonyms LGX818, LGX-818
SMILES code C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC
化学名称 (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate

生物活性

Description
LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
Targets
B-Raf (V600E)
4 nM(EC50)

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (185.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.18 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.52 mL 92.59 mL 185.18mL
0.5 mM 3.7 mL 18.52 mL 37.04 mL
1 mM 1.85 mL 9.26 mL 18.52 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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