Signaling Pathway
重要通知：仅供研究使用。我们不向患者销售。
| Discription | Lifirafenib (BGB-283), also known as Beigene-283, potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. | ||
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| Targets |
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| 目录号 | A16844 |
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| 分子式 | C25H17F3N4O3 |
| 分子量 | 478.42 |
| CAS号 | 1446090-79-4 |
| SMILES | O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1 |
| 其他名称 | BGB283, Beigene-283, BGB 283, Beigene283 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 86 mg/mL (179.76 mM) | |
| Water | Insoluble | ||
| Ethanol | 86 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.9 mL | 104.51 mL | 209.02 mL |
| 0.5 mM | 4.18 mL | 20.9 mL | 41.8 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.9 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
