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Lifirafenib (BGB-283)，也称为Beigene-283，在生化分析中有效抑制RAF家族激酶和EGFR活性，重组BRAFV600E激酶结构域，EGFR和EGFR T790M/L858R突变体的IC50值为23、29和495 nM。
| In vitro | DMSO | 86 mg/mL (179.76 mM) | |
| Water | Insoluble | ||
| Ethanol | 86 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.9 mL | 104.51 mL | 209.02 mL |
| 0.5 mM | 4.18 mL | 20.9 mL | 41.8 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.9 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16844 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 478.42 |
| Formula | C25H17F3N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1446090-79-4 |
| Synonyms | BGB283, Beigene-283, BGB 283, Beigene283 |
| SMILES | O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1 |
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