Lonafarnib (SCH66336)

目录号: A12328

FPTase inhibitor

Lonafarnib (SCH66336) Chemical Structure

CAS NO. 193275-84-2

Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 2,800.00
50 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 1,740.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.
Targets
H-ras (Cell-free assay) N-ras (Cell-free assay) K-ras-4B (Cell-free assay)
1.9 nM2.8 nM5.2 nM
In vitro DMSO 127 mg/mL (198.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol 127 mg/mL (198.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.65 mL 78.27 mL 156.54 mL
0.5 mM 3.13 mL 15.65 mL 31.31 mL
1 mM 1.57 mL 7.83 mL 15.65 mL
5 mM 0.31 mL 1.57 mL 3.13 mL

*The above data is based on the productmolecular weight 638.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12328
MECHANISM OF ACTION Inhibitor
M. Wt 638.82
Formula C27H31Br2ClN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 193275-84-2
Synonyms Sarasar, SCH 66336, SCH66336, SCH-66336
SMILES C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N

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