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Loratadine

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产品目录号: A10538

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Loratadine 10mg A10538-10
¥ 450.00
Loratadine 25mg A10538-25
¥ 800.00
Loratadine 50mg A10538-50
¥ 1,200.00
Loratadine 100mg A10538-100
¥ 1,900.00
Loratadine 10mM * 1mL in DMSO A10538-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Loratadine

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Chemical Information

目录号 A10538
Mechanism of action N/A
分子量 382.39
化学分子式 C22H23ClN2O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 79794-75-5
Synonyms Alavert, Claritin
SMILES code CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
化学名称 Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester

生物活性

Description
Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Targets
H1 receptor B(0)AT2
N/A4 μM

溶解性

Solubility (25°C)* In vitro DMSO 17 mg/mL (44.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 77 mg/mL (201.1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.15 mL 130.76 mL 261.51mL
0.5 mM 5.23 mL 26.15 mL 52.3 mL
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL

*The above data is based on the productmolecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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