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LOXO-101 (ARRY-470, Larotrectinib)

TRK 抑制剂

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产品目录号: A15974


产品名 目录号 价格 数量
LOXO-101 (ARRY-470) 5mg A15974-5
¥ 900.00
LOXO-101 (ARRY-470) 10mg A15974-10
¥ 1,400.00
LOXO-101 (ARRY-470) 50mg A15974-50
¥ 4,200.00



LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.

LOXO-101 (ARRY-470, Larotrectinib)




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Chemical Information

目录号 A15974
Mechanism of action Inhibitor
分子量 428.44
化学分子式 C21H22F2N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1223403-58-4
Synonyms LOXO 101, LOXO101, ARRY470, ARRY 470
SMILES code O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
化学名称 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide


LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.4mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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