LRRK2-IN-1

目录号: A11477

LRRK2 inhibitor

LRRK2-IN-1

LRRK2-IN-1 Chemical Structure

CAS NO. 1234480-84-2

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 2,300.00
50 mg
¥ 4,000.00
10mM * 1mL in DMSO
¥ 1,200.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
Targets
Target Value
DCLK1IC50: 2.61nM
LRRK2(G2019S)IC50: 6nM
LRRK2(WT)IC50: 13nM
DCLK2IC50: 45nM
LRRK2(A2016T)IC50: 2.45μM
LRRK2(A2016T+G2019S)IC50: 3.08μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.54 mL 87.71 mL 175.41 mL
0.5 mM 3.51 mL 17.54 mL 35.08 mL
1 mM 1.75 mL 8.77 mL 17.54 mL
5 mM 0.35 mL 1.75 mL 3.51 mL

*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11477
MECHANISM OF ACTION Inhibitor
M. Wt 570.09
Formula C31H38N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1234480-84-2
Synonyms N/A
SMILES CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

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