Lucatumumab (HCD122) is a fully human monoclonal antibody that functions as an antagonist to CD40, effectively blocking CD40/CD40L-mediated signaling pathways. This antibody is proficient in mediating antibody-dependent cell-mediated cytotoxicity (ADCC), facilitating the clearance of tumor cells. It is primarily utilized in research focused on refractory lymphomas, chronic lymphocytic leukemia (CLL), and multiple myeloma, offering significant insights into therapeutic strategies for these malignancies.
Lucatumumab (HCD122) is a fully human monoclonal antibody that functions as an antagonist to CD40, effectively blocking CD40/CD40L-mediated signaling pathways. This antibody is proficient in mediating antibody-dependent cell-mediated cytotoxicity (ADCC), facilitating the clearance of tumor cells. It is primarily utilized in research focused on refractory lymphomas, chronic lymphocytic leukemia (CLL), and multiple myeloma, offering significant insights into therapeutic strategies for these malignancies.
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