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Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.68 mL | 88.39 mL | 176.77 mL |
| 0.5 mM | 3.54 mL | 17.68 mL | 35.35 mL |
| 1 mM | 1.77 mL | 8.84 mL | 17.68 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
*The above data is based on the productmolecular weight 565.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12279 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 565.7 |
| Formula | C31H36FN3O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1187020-80-9 |
| Synonyms | ITI-007, ITI007, ITI 007 |
| SMILES | O=C(C1=CC=C(F)C=C1)CCCN2CC[C@@](N3CCN(C)C4=C3C5=CC=C4)([H])[C@@]5([H])C2.O=S(C6=CC=C(C)C=C6)(O)=O |
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