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LY-411575

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Gamma secretase 抑制剂

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产品目录号: A11176

库存状态:中国现货中国现货 Shipped in 7-10 Days

产品名 目录号 价格 数量
LY-411575 5mg A11176-5
¥ 900.00
LY-411575 10mg A11176-10
¥ 1,600.00
LY-411575 50mg A11176-50
¥ 5,800.00
LY-411575 100mg A11176-100
¥ 9,600.00
LY-411575 10mM * 1mL in DMSO A11176-10mM-D
¥ 1,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

LY-411575

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY-411575 发表的文献 (3)
  • Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452

Chemical Information

目录号 A11176
Mechanism of action Inhibitor
分子量 479.48
化学分子式 C26H23F2N3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 209984-57-6
Synonyms LY411575
SMILES code C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
化学名称 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide

生物活性

Description

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Targets
γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM

溶解性

Solubility (25°C) * In vitro DMSO 95 mg/mL (198.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (198.13 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.86 mL 104.28 mL 208.56mL
0.5 mM 4.17 mL 20.86 mL 41.71 mL
1 mM 2.09 mL 10.43 mL 20.86 mL
5 mM 0.42 mL 2.09 mL 4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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