Trusted by 10,000+ Scientists since 2006



Gamma secretase 抑制剂

0 Customer Reviews
产品目录号: A11176

库存状态:中国现货中国现货 Shipped in 7-10 Days

产品名 目录号 价格 数量
LY-411575 5mg A11176-5
¥ 900.00
LY-411575 10mg A11176-10
¥ 1,600.00
LY-411575 50mg A11176-50
¥ 5,800.00
LY-411575 100mg A11176-100
¥ 9,600.00
LY-411575 10mM * 1mL in DMSO A11176-10mM-D
¥ 1,200.00



LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY-411575 发表的文献 (3)
  • Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452

Chemical Information

目录号 A11176
Mechanism of action Inhibitor
分子量 479.48
化学分子式 C26H23F2N3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 209984-57-6
Synonyms LY411575
SMILES code C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
化学名称 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide



LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM


Solubility (25°C) * In vitro DMSO 95 mg/mL (198.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (198.13 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.86 mL 104.28 mL 208.56mL
0.5 mM 4.17 mL 20.86 mL 41.71 mL
1 mM 2.09 mL 10.43 mL 20.86 mL
5 mM 0.42 mL 2.09 mL 4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.




Keywords:购买 LY-411575 | LY-411575 供应商 | 订购 LY-411575 | LY-411575 价格 | LY-411575 生产商 | 订单 LY-411575 | LY-411575 代理商 | 购买 209984-57-6| 209984-57-6 供应商 | 订购 209984-57-6 | 209984-57-6 价格 | 209984-57-6 生产商 | 订单 209984-57-6 | 209984-57-6 代理商|buy LY-411575 | LY-411575 Supplier | purchase LY-411575 | LY-411575 cost | LY-411575 manufacturer | order LY-411575 | LY-411575 distributor | buy 209984-57-6| 209984-57-6 Supplier | purchase 209984-57-6 | 209984-57-6 cost | 209984-57-6 manufacturer | order 209984-57-6 | 209984-57-6 distributor