LY-411575

Name: LY-411575
SKU: A11176

目录号: A11176

Gamma secretase 抑制剂

Product Citations (5)

LY-411575 Chemical Structure

CAS NO. 209984-57-6

LY-411575是一种选择性的，细胞可渗透的小分子γ-secretase抑制剂。在表达APP或NΔE的HEK293细胞中IC50为0.078 nM/0.082 nM(基于膜/细胞)，也抑制Notch分裂，IC50为0.39 nM。

库存：现货 Shipped in 7-10 Days

规格	价格	数量
5 mg	￥ 650.00
10 mg	￥ 1,100.00
50 mg	￥ 4,300.00
100 mg	￥ 6,650.00
10mM * 1mL in DMSO	￥ 1,000.00

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产品详情

生物活性

靶点信息

γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE)	γ secretase (cell-based) (HEK293 cells expressing either APP or NδE)	Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM	0.082 nM	0.39 nM

溶解度 *

In vitro (25°C)	DMSO	94 mg/mL (196.04 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (27.11 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.86 mL	104.28 mL	208.56 mL
0.5 mM	4.17 mL	20.86 mL	41.71 mL
1 mM	2.09 mL	10.43 mL	20.86 mL
5 mM	0.42 mL	2.09 mL	4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11176
作用机制	Inhibitor (抑制剂)
M. Wt	479.48
Formula	C26H23F2N3O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	209984-57-6
Synonyms	LY411575
SMILES	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O