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LY2562175是体外有效的选择性FXR激动剂，其EC50值为193 nM。具有强大的脂质调节特性，可降低临床前物种中的LDL和甘油三酸酯，同时提高HDL。
| In vitro | DMSO | 91 mg/mL (168.38 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (1.85 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.5 mL | 92.52 mL | 185.03 mL |
| 0.5 mM | 3.7 mL | 18.5 mL | 37.01 mL |
| 1 mM | 1.85 mL | 9.25 mL | 18.5 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
*The above data is based on the productmolecular weight 540.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17016 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 540.44 |
| Formula | C28H27Cl2N3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1103500-20-4 |
| Synonyms | LY 2562175, LY-2562175 |
| SMILES | O=C(C1=CN(C)C2=C1C=CC(N3CCC(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)CC3)=C2)O |
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