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LY2603618 (IC-83)


Chk 抑制剂

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产品目录号: A11036


产品名 目录号 价格 数量
LY2603618 5mg A11036-5
¥ 900.00
LY2603618 10mg A11036-10
¥ 1,400.00
LY2603618 50mg A11036-50
¥ 4,200.00
LY2603618 100mg A11036-100
¥ 7,000.00
LY2603618 (IC-83) 10mM * 1mL in DMSO A11036-10mM-D
¥ 950.00



LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.

LY2603618 (IC-83)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY2603618 (IC-83) 发表的文献 (1)
  • Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732

Chemical Information

目录号 A11036
Mechanism of action Inhibitor
分子量 436.3
化学分子式 C18H22BrN5O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 911222-45-2
Synonyms LY-2603618
化学名称 N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea


LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents.
Chk1 (Cell-free assay)


Solubility (25°C) * In vitro DMSO 13 mg/mL (29.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% DMSO, 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.92 mL 114.6 mL 229.2mL
0.5 mM 4.58 mL 22.92 mL 45.84 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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